Chemical ototoxicity

Some chemicals can damage hearing. Their exposure must also be assessed when it coincides with noise.

In brief

Some chemicals can damage hearing. Their exposure must also be assessed when it coincides with noise.

Contents
  1. What is ototoxicity?
  2. Combined exposure
  3. Recognise the agents
  4. Controls that must be combined
  5. Industrial cleaning example
  6. Coordination with health surveillance
  7. Related concepts
  8. References

A–Z dictionary →

What is ototoxicity?

Ototoxicity is the ability of certain substances to affect structures or functions associated with hearing and, in some cases, balance. Occupational prevention must not limit hearing analysis to noise levels. Chemical exposure can contribute to harm and modify the risk of hearing loss.

Combined exposure

Coinciding noise and certain ototoxic agents may cause more harm than either exposure separately. Chemical inventory, tasks and noise measurements should therefore be connected. It is not enough for two independent assessments to appear favourable: possible interactions and limitations of reference values used in decisions must be reviewed.

Recognise the agents

Groups requiring attention include certain solvents, metals and gases, although not every member of each group has the same effect. Identification must rely on the specific substance and reliable toxicological information. The safety data sheet helps but may need supplementation with specialist sources and prevention service advice.

Controls that must be combined

Eliminating or substituting hazardous agents where possible and reducing emissions and noise at source take priority. Hearing protectors attenuate sound but do not prevent solvent uptake by inhalation or skin contact. Chemical protection and technical measures address those routes. No personal equipment should justify omitting feasible process controls.

Industrial cleaning example

In a hypothetical case, a person cleans parts with a formulation containing toluene in a noisy area. Joint review considers composition, ventilation, skin contact and acoustic exposure. Changing only earmuffs does not resolve the combination. The cleaning process is examined and effectiveness of implemented measures checked.

Coordination with health surveillance

The healthcare team needs relevant exposure information to guide follow-up. A hearing abnormality requires assessment of various causes and does not automatically establish chemical toxicity. Collective data can help identify patterns while protecting individual information. Prevention should act on identified risk rather than waiting for damage before improving conditions.

References

  1. NIOSH: pérdida auditiva inducida por sustancias químicas. Official source
  2. NIOSH: sustancias ototóxicas y pérdida auditiva laboral. Official source

Editorial information

Publication date: 1 November 2026.

Editorial responsibility: Sabentis Editorial Team.

Author: Pablo RodríguezLinkedIn

Executive Vice President of the ORP International Foundation and Chief Financial Officer of Sabentis.

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